Successful heart and liver transplantation in a Swiss patient with Glu89Lys transthyretin amyloidosis.
نویسندگان
چکیده
LLS for small babies, especially when the graft has multiple hepatic veins. Seisuke Sakamoto Takanobu Shigeta Ikumi Hamano Akinari Fukuda Toshihiko Kakiuchi Naoto Matsuno Hideaki Tanaka Atsuko Nakagawa Mureo Kasahara 1 Division of Transplant Surgery National Center for Child Health and Development Tokyo, Japan 2 Division of Pediatric Surgery National Center for Child Health and Development Tokyo, Japan 3 Division of Pathology National Center for Child Health and Development Tokyo, Japan This work was supported, in part, by grants from the Scientific Research Fund of the Ministry of Education and by a research grant for immunology, allergy and organ transplant from the Ministry of Health, Labor and Welfare, Japan, and Foundation for Growth Science, Japan. Address correspondence to: Seisuke Sakamoto, M.D., Ph.D., 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan. E-mail: [email protected] S.S. and M.K. participated in research design, data analysis, and writing of the manuscript; T.S., A.F., I.H., T.K., and A.N. participated in data analysis; and N.M. and H.T. participated in research design. Received 4 October 2010. Accepted 24 November 2010. Copyright © 2011 by Lippincott Williams & Wilkins ISSN 0041-1337/11/9106-38 DOI: 10.1097/TP.0b013e3182088bb5
منابع مشابه
Successful Diflunisal Desensitization in a Transthyretin Amyloidosis Patient with NSAID Allergy: A Case Report
Introduction: Amyloid diseases have been known to be hereditary, including transthyretin (TTR) amyloidosis where subunit protein mutations may occur in genes for TTR leading to the deposition of fibrils (low molecular weight subunits (5 to 25 kD) of proteins) in extracellular tissues. By reducing the formation of TTR amyloid, diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), has shown ...
متن کاملWhat to do when the neuropathy worsens after successful heart and liver transplantation in a Glu89Lys Transthyretin Amyloidosis?
Results After her double transplantation, the patient reported over the 8 subsequent years slowly progressive increasing pain and loss of sensation in the feet, slow bowel habit, and delayed urine flow. On examination, we found orthostatic hypotension, sensory loss, muscle weakness, and mild atrophy in the distal lower extremities with reduced Achilles tendon reflexes. Nerve conduction studies ...
متن کاملAmyloid Polyneuropathy and Myocardial Amyloidosis 10 Years after Domino Liver Transplantation from a Patient with a Transthyretin Ser50Arg Mutation
A 54-year-old man with polycystic liver disease received a domino liver transplantation (DLT) from a patient of hereditary ATTR amyloidosis with the transthyretin Ser50Arg mutation. Ten years after transplantation, he felt a slight numbness in his toes, and cardiac amyloidosis was simultaneously suspected upon a heart function evaluation. Biopsy specimens from the myocardium revealed transthyre...
متن کاملATTR-FAP: liver transplantation vs oral medication, how and when
Background Liver transplantation (LTx), introduced in 1990, has served as the only available treatment with capacity to halt the progress of disease in transthyretin amyloidosis. For the most common variant, Val30Met, the effect of a new liver is well known leading to stabilization in the majority of patients. However, not all patients are helped by transplantation. Progress of cardiac amyloido...
متن کاملA Heart too Stiff to Beat: A Case of Familial Transthyretin Amyloidosis Cardiomyopathy
Heart failure is a common clinical syndrome caused by a variety of cardiac diseases. We report a rare case of familial transthyretin amyloidosis cardiomyopathy to heighten the awareness of this rare but lethal cause of heart failure, as therapeutic interventions such as liver or heart transplant could be curative in selected patients.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Transplantation
دوره 91 6 شماره
صفحات -
تاریخ انتشار 2011